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You Need to Know About Human Metapneumovirus (hMPV) ## **What You Need to Know About Human Metapneumovirus (hMPV)**   Human metapneumovirus (hMPV) is a respiratory virus causing flu- or cold-like symptoms. While generally mild, it can lead to severe complications such as **bronchitis or pneumonia**, particularly in vulnerable groups such as **infants, the elderly, and immunocompromised individuals**. Recent reports of increased cases in China have raised public concerns, but experts confirm the risk of a pandemic similar to COVID-19 is **low**.   --- ### **Key Facts About hMPV**   - **Family of Viruses**: hMPV belongs to the same virus family as respiratory syncytial virus (RSV).   - **Discovery**: First identified in the Netherlands in **2001**, though it has likely circulated for much longer.   - **Seasonality**: Cases peak during colder months, such as **winter and early spring**, similar to RSV and influenza.   ---info- gra...

ADEM INTRODUCTION ADEM is an inflammatory, demyelinating event of early childhood presenting with an acute onset of polyfocal neurologic deficits, accompanied by encephalopathy and changes compatible with demyelination on brain MRI Epidemiology Although ADEM can occur at any age, most series reporta mean age of between 5 and 8 yr with a slight male predominance. The reported incidence ranges from 0.1-0.6 per 100,000 per year in the pediatric population. ADEM is usualy monophasic, but recurrence can occur; if the recurrence is 3 mo or longer after the first episode, the condition is termed multiphasic disseminated encephalomyelitis (MDEM). Up to 50% of cases of ADEM have been found to be associated with MOG-Ab (Myelin oligodendrocyte glycoprotien) positivity in the serum, and almost all cases of MDEM are MOG-Ab positive; there is thus a strong likelihood that as MOG-Ab testing becomes more available, cases of non-MOGAb positive MDEM will become exceptionally rare. An episode of ADEM can...

 

 ** Acute Appendicitis: Key Facts to Know!** 🔹 **Epidemiology**:   - Most common in ages 10–19   - More frequent in boys and men   🔹 **Clinical Symptoms**:   - Right lower quadrant (RLQ) abdominal pain   - Nausea, vomiting, anorexia   - Periumbilical pain moving to RLQ   - Fever   🔹 **Atypical Symptoms**:   - Dyspepsia, flatulence   - Bowel irregularity, diarrhea   - General malaise   🔹 **Physical Exam Findings**:   - **McBurney Point**: Pain 2/3 distance from umbilicus to anterior superior iliac spine   - **Rovsing Sign**: Palpation in LLQ causes pain in RLQ   - **Psoas Sign**: Pain on hip extension (retrocecal appendicitis)   - **Obturator Sign**: Pain on internal rotation of the hip (pelvic appendicitis)   🔹 **Management**:   - Appendectomy is the treatment of choice   - Antibiotics rese...